“The ethical use of Psychotropic drugs is perhaps the single most important aspect of Psychiatric care that requires urgent attention” ~ Dr Phil Thomas
I watched the movie All that Heaven Allows (1955). There is a line in it where Jane Wyman goes to the doctor after the breakup of a relationship and he says “Do you expect me to give you a prescription to cure life?”. While there are some tranquilizers that can help people short term, there is no prescription that will cure life’s emotional problems, some of which may have stemmed from trauma in a person’s past or more recent distress.
There has to be a better way than drugging people into oblivion or disabling a person’s cognitive abilities as part of “treatment”. Anatomy of an Epidemic by medical journalist Robert Whitaker researched the disabling and devastating effects of overprescribing in the US [1].
Medication can actually intensify or magnify mental health problems for some of us. I personally found that some tranquilizers can help short term, but long term these drugs fuelled my symptoms, caused damage and delayed my healing. While a person may need some tranquilizers if in acute distress, what they really need is someone to listen with empathy non-judgmentally, to try to understand what’s happening and set them on the right path.
Adverse effects of Prescribed Psychotropic substances
Prescribed psychotropic substances can have very damaging effects, especially when used long term. In 2005, a study funded by Eli Lilly, the maker of Zyprexa / Olanzapine, found that long term exposure to this major tranquilizer causes shrinkage of the brain, “significant reduction in brain volume that affects both gray and white matter” [2]. I first learned this from honest Psychiatrists Dr Peter Breggin and Dr Joanna Moncrieff. After I had an adverse reaction to the drug Citalopram, I was put on Olanzapine at what I now consider too high a dosage (10mg) long term in 2008. I did not have informed consent about this powerful but potentially damaging drug. There are no words to describe my shock and feeling of being let down by the medical profession when I learned the truth. The damage is there and can be felt in subtle ways. I have to be compassionate with myself and hope that neuroplasticity will help, which is the brain’s ability to repair some of the damage and injury.
Over three years I was given Olanzapine, Seroquel/Quetiapine, Lamictal, Lithium, Rivotril and a number of other drugs. No doctor seemed to care about the weight gain or damage their overprescribing caused. I gained 25 lbs and it took many years to lose this weight again. There are lawsuits in the US relating to the drug Zyprexa / Olanzapine [3]. According to Robert Whitaker (in his book Anatomy of an Epidemic) twenty people died in the trial for Zyprexa which is a scandal in itself.
Withdrawal from prescribed psychoactive substances
It is necessary to be cautious with Psychiatric medication. It’s easier to get on them than to get off and easier to prescribe than deprescribe. While some people may want to stay on these drugs, those who would like to come off prescribed drugs should be supported and given alternatives.
It is very difficult to have a proper recovery in a system that revolves around the biomedical model. Some people are told they will be on drugs for life and are called “non-compliant” if they try to go down an alternative route. Coming off these drugs will usually be severely frowned upon. You are basically left to your own devices in what can be a very difficult process.
Sometimes people are taken off the drugs too fast, leading to failure, but this can also take away hope of ever becoming drug free. Withdrawal has to be done very slowly, under the supervision of an expert who has the most up to date, honest psychopharmacological information on the withdrawal process. I’ve added a section entitled Resources to help withdraw from prescribed Psychoactive drugs.
Supporters and family need truthful information and advice about the withdrawal process. It is important to prepare well for withdrawal with nutrition, exercise, getting enough sleep (if possible), talking therapy and holistic work on health.
Relapse on discontinuation of psychoactive drugs can be a form of drug withdrawal state [4]. A person may experience return of symptoms while coming off the drugs. In the current biomedical system, any relapse will usually be seen as a sign of “illness” as opposed to the process of withdrawal.
In 2011, when I was trying to withdraw from the drugs, I was told by a doctor in a disapproving tone “These drugs are not made for a’la carte people like you!”. That particular day was a major turning point and I’m grateful for his valuable one liner. I knew for sure I wanted to get off these drugs. However, without support from doctors or others, it was a bumpy ride.
When I was coming off the drugs I got no support or correct advice. In the first 2 years I was prone to relapse, as my brain/body readjusted. I did keep some Olanzapine 5 mg on standby during that time. I am now drug free for several years. Sleep is an important part of the healing journey and something I struggle with since the overuse of these psychoactive substances. I never get a full night’s sleep and continue to work on that. My circadian clock is also out of sync. Circadian rhythm is an internal process that regulates the sleep / wake cycle.
Yearly explosion in prescribing of antidepressants
An article in the Sunday Business Post (SBP) by Susan Mitchell in February 2018 investigated our growing dependence on prescribed painkillers and psychoactive substances. “From antidepressants to sedatives, from painkillers to sleeping pills, the use of prescription medication is spiralling” [5]. Some of the headlines in this edition of the SBP include “We are definitely overprescribing. We’ve all seen what has happened in America, so we can’t be complacent. The figures are fairly stark”.
“In 2016, €25 million was spent on the drug (Lyrica / Pregabalin which is a neuropathic pain drug) for medical card holders – up from €5 million in 2006” (1086% increase). “The number of prescriptions for the SSRI (antidepressant) Lexapro soared from 190,109 to 631,000 – a 232 % increase” (2006 to 2016). Sertraline prescriptions are up 252%. And Venlafaxine (Effexor) prescriptions up 107%. These are shocking increases in drug use.
The money used on the over prescribing of painkillers and Psychotropic drugs could be redirected into a more humane system. But that would require a major shift in thinking from the current biomedical based model to a system that is based more on a Psychosocial and holistic approach to healing.
For example, the Power Threat Meaning Framework describes an “alternative to Psychiatric classification in relation to emotional distress” [6]. One of the lead authors, clinical Psychologist Dr Lucy Johnstone, came to Dublin in May 2018 to talk about this approach. She was invited by the youth mental health charity Jigsaw.
Do doctors give out antidepressants too easily?
In April 2013 The Right Hook (presented by George Hook on Newstalk) discussed an article in the Irish Examiner which saw journalism student Niamh Drohan approach seven GPs telling them she was suffering from stress and anxiety problems from her final year in college [8]. All of the GPs diagnosed her with a mild form of depression. All doctors prescribed her with antidepressants.
I was in shock at what I heard on The Right Hook. A doctor went on the show and claimed that these drugs are not addictive and far more seriously she claimed during the interview that antidepressants are safe at overdose levels. Her exact words were “Not even dangerous at high levels at overdose”. Nothing could be further from the truth. A number of years ago, in a documentary on suicide, I heard a doctor say that if someone takes an overdose of certain prescription drugs they can end up alive and brain damaged.
In Ireland in 2009 the very tragic Shane Clancy case involved an overdose of the SSRI antidepressant drug Citalopram. SSRI is a Selective Serotonin Reuptake Inhibitor. The tragedy happened 17 days after starting this mind-altering drug. Thankfully Shane Clancy’s mother Leonie Fennell and Prof David Healy got to speak on the George Hook show shortly after that.
Evidence Based Medicine (EBM)
I’ve included a presentation by Prof David Healy [9]. 6 minutes into the presentation you will see that the negative trials on SSRI antidepressants have been hidden.
Evidence Based Medicine is broken is an article from the British Medical Journal (2014) written by Scottish GP Des Spence [10] ~
“Now doctors can prescribe a pill for every ill… Medical experts who should be providing oversight are on the take…the current incarnation of EBM (Evidence Based Medicine) is corrupted, let down by academics and regulators alike. What do we do? We must first recognise that we have a problem.”
The following is a quote from Psychiatrist Dr Allen Frances (chair of the taskforce that wrote the DSM-IV) “It’s been many years since I have trusted anything I read in a medical or psychiatric journal. There is an enterprise-wide positive bias; findings never seem to replicate; benefits are hyped; harms are hidden” [11]. In academic research it’s important to know who funded the research and if there was any pharmaceutical company linked to it, which can create a conflict of interest.
Placebo
This is from an article by Charlotte Blease [12]. Irving Kirsch is a Harvard Professor.
“The placebo effect is a genuine therapeutic mind-body effect … The branding, the expensiveness, the colouration of pills, the number of times you have to take them per day … can increase the placebo effect … Kirsch and his colleagues discovered that antidepressants are not more effective than placebos for mild to moderate depression”. At the same time there are a significant number of us that antidepressants are not suited to and these drugs made our symptoms worse.
DSM (Diagnostic and Statistical Manual)
Mental health is an area where there are powerful vested interests. The pharmaceutical industry is a multi-billion dollar industry. This has a major impact on the approach taken in treating people and the fact that the biomedical model is still dominant.
DSM stands for Diagnostic and Statistical manual and is now at revision 5. When 69 % of the DSM-5 taskforce had financial links to the pharmaceutical industry, this leads to overdiagnosis and overprescribing of drugs. These drugs can delay recovery and cause disability leading to a huge burden on the social welfare system. This burden could be reduced with more ethical prescribing and more honesty about the drugs.
The biomedical model is the dominant approach in use but it can cost the individual and society a lot in the long run. It is possible to get people through recovery and back to being a productive member of their community faster. This is not always possible if the person is on high doses of strong tranquilizers which can affect their ability to function e.g. in a work environment.
Conflicts of Interest
In 2016 one high profile doctor and author, that promotes the use of antidepressants and influences public opinion, received a payment of €32,000 from Lundbeck. As someone that regularly speaks via the media, Ive never heard him publicly declare this serious conflict of interest.
“Doctors, consultants and other medical practitioners will be obliged to declare gifts or donations from pharmaceutical and healthcare companies under new legislation” [13].
“The HSE wants pharmaceutical companies to name those in receipt of payments for travel, sponsorship, medical education, grants and other activities” [14].
“Irish doctors share €6.8m payments from pharma companies” [15]. “Details of the payments made by IPHA (Irish Pharmaceutical Healthcare Association) members and some other companies are available in the report on transferofvalue.ie. Subsequent reports will be published on a yearly basis and made publicly available for three years”.
When doctors speak publicly or in court they should declare any conflicts of interest. It can potentially result in the public being uninformed about the serious risks that go with certain drugs.
GP training in mental health
“Most GPs in Ireland do not have specific training in mental health. In the sample of GPs questioned in the SWAHB survey, 68% indicated they had no specific training in mental health” Vision for Change policy document [16].
That is a staggering statistic. Hopefully it has improved since this document was written. I personally feel that GPs should have more training in mental health. That is where a lot of emotional issues are dealt with. In my experience a prescription for pills rarely solves anything long term and can sometimes cause more harm than good. While doctors can be supportive, they work under time pressure in busy surgeries. Inadequate training can lead to damage to the patient and long-term trauma. There has to be a better system than the current one.
The Power of your Subconscious mind
The Power of your Subconscious mind is a book by Dr Joseph Murphy [17]. Here is a quote from it: “You should carefully watch all ideas and thoughts entertained in your conscious mind”…”You can interfere with the normal rhythm of your heart, lungs, and other organs by worry, anxiety and fear. Feed your subconscious with thoughts of harmony, health and peace”. A doctor’s suggestions and opinions can also impact our subconscious mind.
I was initially informed by a doctor that I would need to be on the antidepressant Citalopram for the rest of my life to treat anxiety and panic attacks. When this drug caused an adverse reaction, including mania, I was taken off this drug cold turkey by someone in the mental health system. The serious issue of withdrawal was never considered or mentioned. I was told I was ill and had a disorder. Bipolar Affective Disorder. BPAD for short in doctor’s notes.
From reading and researching the work of honest Psychiatrists I eventually started to realise the drugs were contributing to my symptoms. The extreme lows and lethargy as well as the highs and altered sense of reality. Becoming aware of this was a major turning point in my healing journey but breaking free from the indoctrination of the flawed biomedical approach was no easy task.
I could still be living the illness and disorder model of mental health but decided that believing in this was unhelpful, harmful and kept me stuck. “It is foolish to believe in sickness or in anything that will hurt or harm you. Believe in perfect health, prosperity, peace, wealth and divine guidance” Joseph Murphy.
In my experience mainstream Psychiatry is a belief system. One that is very lucrative for the pharma industry and doctors but not very helpful long term for the person in distress, who wants to heal and live a productive life. Natural balance, harmony, meaning, purpose and Peace of Mind are important to me. I still have days that I struggle and those are the days I need to stay self-aware, rest and be kind to myself. Mental and physical health requires daily work and the ability to deal with any setbacks. I feel hopeful of healing. When sedated with drugs I felt no real hope at all. I am a work in progress, but a lot further along the road than if I continued in the biomedical view of emotional distress.
References
[1] Anatomy of an Epidemic by Robert Whitaker, 2010 ~
www.amazon.com/Anatomy-Epidemic-Bullets-Psychiatric-Astonishing/dp/1491513217
[2] “The Influence of Chronic Exposure to Antipsychotic Medications”, 2005 ~ www.nature.com/articles/1300710/email/correspondent/c1/
[3] Lilly Settles With 18,000 Over Zyprexa / Olanzapine ~ www.nytimes.com/2007/01/05/business/05drug.html
[4] Psychiatry in Context : Experience, Meaning & Communities, Dr Philip Thomas, 2015 ~
www.amazon.com/Psychiatry-Context-Experience-Meaning-Communities/dp/1906254729
[5] Hooked: Ireland’s hidden addiction to prescription drugs, Sunday Business Post, Susan Mitchell, Feb 2018 ~
www.businesspost.ie/health/hooked-irelands-hidden-addiction-to-prescription-drugs-b7fce3be
[6] The Power Threat Meaning Framework overview ~ Lead authors Dr Lucy Johnstone (clinical Psychologist) and Prof Mary Boyle, 2018 ~
www.bps.org.uk/power-threat-meaning-framework
[7] Main talks from the Power Threat Meaning Framework launch, 2018 ~
https://vimeo.com/267401691
[8] “Depressing truth about treating depression in the young” Niamh Drohan ~ www.irishexaminer.com/news/arid-20227126.html
[9] “Time to abandon evidence based medicine?” Prof David Healy (2012) ~ www.youtube.com/watch?v=A3YB59EKMKw
[10] Evidence based medicine is broken, GP Des Spence, 2014 ~ www.bmj.com/content/348/bmj.g22
[11] The Crisis of Confidence in Medical Research, Dr Allen Frances, 2015 ~ www.psychologytoday.com/us/blog/dsm5-in-distress/201501/the-crisis-confidence-in-medical-research
[12] “Research on the placebo effect is a bitter pill for pharmaceutical firms to swallow” Dr Charlotte Blease, 2015 ~
www.herald.ie/lifestyle/research-on-the-placebo-effect-is-a-bitter-pill-for-pharmaceutical-firms-to-swallow-31219408.html
[13] Bill will require doctors to declare gifts from pharma firms. Healthcare companies gave €30 million to hospitals, medical staff in 2016, says Minister ~
www.irishtimes.com/news/politics/oireachtas/bill-will-require-doctors-to-declare-gifts-from-pharma-firms-1.3263608
[14] HSE warns pharma firms about payments to doctors, 2017 ~
www.businesspost.ie/health/hse-warns-pharma-firms-about-payments-to-doctors-5f272f97
[15] Irish doctors share €6.8m payments from pharma companies, 2016 ~
www.irishtimes.com/news/health/irish-doctors-share-6-8m-payments-from-pharma-companies-1.2705795
[16] Vision for Change (Report of the expert group on Mental Health Policy), 2006 ~
www.hse.ie/eng/services/publications/Mentalhealth/Mental_Health_-_A_Vision_for_Change.pdf
[17] The Power of Your Subconscious Mind, Dr Joseph Murphy, 2011 (Reprint of 1963 Edition) ~
www.amazon.com/Power-Your-Subconscious-Mind/dp/1614270198
Other Relevant Information
* Massive rise in antidepressant prescribing ~
www.rte.ie/news/investigations-unit/2019/0218/1031271-massive-rise-antidepressant-prescribing/
* Study 329 – where the hell is the outrage? by Dr Malcolm Kendrick ~
www.drmalcolmkendrick.org/2015/10/01/study-329-where-the-hell-is-the-outrage/
* John Rengen Virapen ~ Pharma whistleblower ~ www.youtube.com/watch?v=pmnOni0xlM4
* Dr. Allen Frances on the Risks of DSM-5 (Diagnostic and Statistics Manual) ~
www.youtube.com/watch?v=-AMvrcBvYWk
* Does long term use of psychiatric drugs cause more harm than good? ~
www.bmj.com/content/350/bmj.h2435
* AstraZeneca Settles Most Seroquel Suits ~
https://prescriptions.blogs.nytimes.com/2011/07/28/astrazeneca-settles-most-seroquel-suits/
* SPECIAL REPORT: The anti-depressant generation ~
www.irishexaminer.com/news/arid-20319128.html
* Our €40m drug problem ~
www.irishexaminer.com/opinion/commentanalysis/arid-20319134.html
* Recording from The International Society for Ethical Psychology & Psychiatry (ISEPP) Conference. A mother (nurse) speaks of how difficult it was for her son to come off Paxil (Seroxat).
www.youtube.com/watch?v=R8ReARNiAHI
* Yolande Lucire ~ Adverse reactions to Psychiatric drugs:
www.youtube.com/watch?v=IEoSs6Yo0DA&feature=youtu.be
* Outcome of mood disorders before psychopharmacology: a systematic review.
“This review provides no support to the belief that pharmacological treatments have resulted in an improvement in the long-term outcome of patients with mood disorders”.
www.ncbi.nlm.nih.gov/m/pubmed/24285565/
* Deadly Medicines and Organised Crime: How big pharma has corrupted healthcare,
Peter Gøtzsche, 2013 ~
www.amazon.com/Deadly-Medicines-Organised-Crime-Healthcare/dp/1846198844
* Deadly Psychiatry and Organised Denial, Peter Gøtzsche, 2015 ~
www.amazon.com/Deadly-Psychiatry-Organised-Denial-Gotzsche-ebook/dp/B014SO7GHS
* Interview with Peter Gøtzsche (co-founder of the Cochrane Collaboration) ~
www.youtube.com/watch?v=VIIQVll7DYY
* The Emperor’s New Drugs: Exploding the Antidepressant Myth, Irving Kirsch, 2009 ~
www.amazon.com/The-Emperors-New-Drugs-Antidepressant/dp/0465022006
* Psychiatrist / Psychopharmacologist David Healy, Making Medicines safer for all of us ~
www.davidhealy.org
* Will Self ~ Psychiatrists: the drug pushers ~
www.theguardian.com/society/2013/aug/03/will-self-psychiatrist-drug-medication
* Government needs to see mental health as an economic issue, Keith Gaynor ~ www.independent.ie/opinion/analysis/government-needs-to-see-mental-health-as-an-economic-issue-30104711.html
Information and Resources to help with withdraw from prescribed Psychoactive drugs
* Inner Compass initiative ~ www.theinnercompass.org/
* Psychiatric Drug Withdrawal –
A Guide for Prescribers, Therapists, Patients and their Families ~
http://breggin.com/a-guide-for-prescribers-therapists-patients-and-their-families/
* Stopping antidepressants – Royal College of Psychiatrists in the UK (2020) –
www.rcpsych.ac.uk/mental-health/treatments-and-wellbeing/stopping-antidepressants
* Stopping Antidepressants (under supervision of medical professional) ~
https://rxisk.org/guide-stopping-antidepressants/
* An independent drug safety website to help you weigh the benefits of any medication against its potential dangers. www.rxisk.org
* Council for Evidence Based Psychiatry. Includes a support page, Recovery stories and withdrawal advisors ~ www.cepuk.org
* A systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence based? James Davies and John Read, 2019
www.sciencedirect.com/science/article/pii/S0306460318308347